No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?

Hannes Mogensen, Fredrik Bengtsson and Henrik Jörntell recently published an article in The Cerebellum. Where they investigated the mechanism underlying plasticity in the cerebellum.

In order to understand the mechanism underlying plasticity in the cerebellum, an important piece of information is the efficacy of long term potentiation between mossy fiber inputs and deep cerebellar nuclei. Previous studies has shown that plasticity can be induced on a medium-term time scale (less than an hour) in juvenile slices, however our results show that for the adult brain in an in vivo setting, the effect is non-existing or at least an order of magnitude smaller than has been hitherto reported.

For further reading, head over to the article.